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Spegra Tablet
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Emcure

Spegra Tablet

₹4,388.50 Original price was: ₹4,388.50.₹2,699.00Current price is: ₹2,699.00.

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  • Dolutegravir (50mg)
  • Emtricitabine (200mg)
  • Tenofovir Alafenamide (25mg)
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Description

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About Spegra Tablet

Salt : Dolutegravir (50mg) + Emtricitabine (200mg) + Tenofovir Alafenamide (25mg)

Product Introduction

Spegra Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome).

Spegra Tablet restricts the growth of HIV in the body and reduces the risk of getting HIV-related complications to improve the lifespan of an individual. The medicine can be taken with or without food. Taking these medicines regularly at the same time increases their effectiveness. A dose of this medicine should not be missed as it can affect your recovery. It is important to complete the full course of the treatment until your doctor advises you to stop it. Sudden discontinuation of the treatment may affect the potency of the medicine.

The most common side effects of this medicine are insomnia, fatigue, headache, nausea, adn diarrhea. These side effects are generally temporary, but if they persist or become serious inform your doctor. This medicine can also make you feel lazy or weak, so it is advised to avoid driving. Drinking plenty of fluid can help you to cope up with the side effects, so stay hydrated.

Before starting with the treatment, you should consult your doctor if you are pregnant or breastfeeding, or have any health condition. Your doctor may suggest regular blood tests to check your blood counts, kidney and liver functions, and other health conditions. If you are HIV positive, you should not breastfeed or share personal belongings like razors or toothbrushes. Consult your doctor to know about safe sex methods in order to prevent transmission of HIV during intercourse.


Uses of Tablet

  • HIV infection

Benefits of Spegra Tablet

In HIV infection

Spegra Tablet prevents HIV from multiplying in the body. It helps control the infection and make the immune system work better. This lowers the chances of getting complications, such as new infections, and improves the quality of life. This medicine is always taken in combination with other antiretroviral medicines.

It is not a cure of HIV or AIDS and should not be used to prevent HIV after accidental exposure to a risk. It is important to take this medicine as prescribed by the doctor. Taking all doses in the right amount at the right times greatly increases the effectiveness of this combination of medicines and reduces the chances of HIV infection becoming resistant to antiretroviral medicines. Although taking this medicine does not prevent the passing of HIV to other people.


Side effects of Spegra Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Spegra Tablet

  • Insomnia (difficulty in sleeping)
  • Headache
  • Nausea
  • Fatigue
  • Diarrhea

How to use Spegra Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Spegra Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Spegra Tablet works

Spegra Tablet is a combination of three medicines: Dolutegravir, Emtricitabine and Tenofovir Alafenamide. It is an anti-HIV medication and works by preventing the action of reverse transcriptase enzyme. This enzyme is responsible for production of HIV.

Safety Advices

Pregnancy

There is limited information on the use of Spegra Tablet during pregnancy. Inform your physician if you are pregnant or planning to get pregnant during the treatment.

Breast Feeding

Breastfeeding is not recommended in patients taking Spegra Tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.

Lungs

It is unknown whether Spegra Tablet is safe to administer to patients with lung diseases. Inform your physician if you have any lung diseases before initiating the therapy.

Liver

Spegra Tablets should be cautiously administered in patients with liver diseases. Dose adjustments are necessary. However, inform your physician of any liver diseases before initiating the therapy.

Alcohol

It is unsafe to drink alcohol while taking Spegra Tablet. It may reduce the drug’s effectiveness and can cause toxic side effects.

Driving

Spegra Tablet can cause dizziness. It is recommended to avoid driving and operating heavy machinery during the treatment.

Quick tips

  • Spegra Tablet is given to slow the progress of HIV infection.
  • Although treatment with Spegra Tablet can reduce the risk of you passing HIV to others through sexual contact, it does not stop it. It is therefore important to use condoms.
  • If you develop any infection soon after taking Spegra Tablet, inform your doctor. As a result of taking Spegra Tablet, your immune system may start fighting an infection that was present before you started the treatment, but you might not be aware of.
  • It may cause weakening of your bones. Exercise regularly and take calcium and vitamin D supplements as suggested by your doctor.

    Side Effects of Spegra Tablet

    Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

    Serious

    • Hepatitis B reactivation
    • Increased risk of fracture
    • Acute renal failure

    Common 

    • Headache
    • Nausea
    • Diarrhea
    • Fatigue
    • Insomnia

    Word of Advice

    If you are living with HIV or are at risk of contracting the virus, it is crucial to seek medical advice and follow a prescribed treatment plan. Antiretroviral therapy, such as the combination of can significantly improve your health outcomes. However, it is essential to remember that medication adherence is key. Consistently taking your prescribed medication as directed by your healthcare provider and attending regular follow-up appointments will help ensure the effectiveness of the treatment and monitor your progress. Additionally, practicing safe sex, using clean needles, and taking preventive measures can significantly reduce the risk of HIV transmission. Remember to consult with healthcare professionals for personalized advice and guidance tailored to your specific needs and circumstances


    FAQs

    Q 1. Can Spegra Tablet cure HIV?

    Spegra Tablet is not a cure for HIV. It is an antiretroviral medication that helps control the virus, reduce its replication, and slow down the progression of the disease. It is essential to continue taking the medication as prescribed, even if you feel well, to maintain viral suppression and protect your immune system.

    Q 2. Can Spegra Tablet cause changes in cholesterol or blood sugar levels?

    Spegra Tablet may affect some individuals’ cholesterol and blood sugar levels. Regular monitoring of these parameters is recommended, especially in individuals with pre-existing conditions such as diabetes or high cholesterol. Lifestyle modifications or additional treatments may be considered if necessary.

    Q 3. Can Spegra Tablet be used in children and adolescents?

    Spegra Tablet is approved for use in children and adolescents above a certain age and body weight. The appropriate dosage and safety considerations for pediatric populations should be discussed with a pediatric HIV specialist.

    Q 4. Does Spegra Tablet affect the liver?

    People with liver disease, including chronic hepatitis B or C taking antiretrovirals have a higher risk of severe and potentially fatal liver complications. If you have hepatitis B infection, your doctor will carefully consider the best treatment regimen for you.

    Q 5. Is it safe to abruptly stop taking Spegra Tablet

    Abruptly stopping Spegra Tablet without medical guidance can lead to viral rebound and a decrease in treatment effectiveness. It is important to consult with your healthcare provider before changing your HIV treatment regimen.


    Fact Box

    Molecule name: Dolutegravir, Emtricitabine, Tenofovir Alafenamide Therapeutic class: Anti-retroviral
    Pharmacological class:

    1. Dolutegravir: Integrase strand transfer inhibitors

    2. Emtricitabine: Nucleoside reverse transcriptase inhibitor

    3. Tenofovir Alafenamide: Nucleotide reverse transcriptase inhibitor (NtRTI)

    Indications:

    HIV infection 


    References

    1. Descovy 200 mg/25 mg film coated tablets – Summary of Product Characteristics (SmPC) – (emc). www.medicines.org.uk. Published April 2022. Accessed May 22, 2023. https://www.medicines.org.uk/emc/product/2108/smpc
    2. Emtricitabine / Tenofovir Alafenamide – Patient | NIH. clinicalinfo.hiv.gov. Published [February 27, 2023].[Accessed May 22, 2023]. https://clinicalinfo.hiv.gov/en/drugs/emtricitabine-tenofovir-alafenamide/patient#dr1
    3. KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
    4. Gilead Sciences, Inc., US Food & Drug Administration, [Revised on Sep 2017] [Accessed on 22th Aug 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208215s005lbl.pdf
    5. Flexner CW. Antiretroviral Agents and Treatment of HIV Infection. In: Brunton LL, Hilal-Dandan R, Knollmann BC (Editors). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill Education; 2018. pp. 1138-1157.
    6. Safrin S. Antiviral Agents. In: Katzung BG, Masters SB, Trevor AJ (Editors). Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 861-890.
    7. Dolutegravir, emtricitabine and tenofovir alafenamide [FDA Label]. Hyderabad, India: Mylan Laboratories Limited; 2018. [Accessed 16 Apr. 2021] (online) Available from: LINK
    8. Dolutegravir, emtricitabine and tenofovir alafenamide [Prescribing Information]. Anakapalli, India: Laurus Labs Limited; 2023. [Accessed 22 Aug. 2024] (online) Available from: LINK

      All Substitutes For Spegra Tablet

      Kocitaf Tablet

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Spegra Tablet

Spegra Tablet

₹4,388.50 Original price was: ₹4,388.50.₹2,699.00Current price is: ₹2,699.00.
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